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Cisplatin potassium wasting

WebJul 18, 2024 · In fact, Schilsky and colleagues showed that 22 of 29 patients (76%) who received cisplatin for non-seminomatous germ cell tumors developed acute hypomagnesemia; eleven (50%) remained hypomagnesemic for at least 3 years. 83 This long-term effect has been corroborated by other investigators as well. 84, 85 WebApr 1, 2024 · The patient’s laboratory values on admission He was admitted to the hospital and received a total of 230 mmol of potassium intravenously and by mouth over the next 20 hours, but his serum potassium level increased to only 2.9 mmol/L. Therefore, the nephrology service was consulted to evaluate his refractory hypokalemia.

Cisplatin-induced renal salt wasting syndrome - PubMed

WebAug 16, 2024 · Cisplatin-associated electrolyte dysregulation is a prevalent therapy-related adverse effect. There are numerous electrolyte-supplemented hydration regimens that have been evaluated, however these studies focused on the development of nephrotoxicity. WebApr 7, 2015 · Cisplatin-associated acute kidney injury (AKI) occurred in 8% of the patients. Urine neutrophil gelatinase-associated lipocalin to urine creatinine ratio (NGAL/Cr) and … small kitchen swing bin https://bioforcene.com

Protective Effect of Magnesium Preloading on Cisplatin-induced ...

WebOct 5, 2014 · 1. Introduction. Cisplatin (CAS No. 15663-27-1, MF-Cl 2 H 6 N 2 Pt; NCF-119875), cisplatinum, also called cis-diamminedichloroplatinum(II), is a metallic (platinum) coordination compound with a square planar geometry.It is a white or deep yellow to yellow-orange crystalline powder at room temperature. It is slightly soluble in water and soluble … WebDec 13, 2024 · The electrolytes affected are primarily mineral ions, specifically potassium, calcium, magnesium, sodium, and chloride. Fundamentally, like Bartter’s syndrome, Gitelman syndrome is a salt wasting nephropathy. The symptoms and severity of the disorder can vary greatly from one person to another and can range from mild to severe. WebJul 22, 2024 · Exposure of tubular cells to cisplatin activates complex signaling pathways that result in tubular cell injury and cell death. A robust inflammatory response, as well as … small kitchen stove top

Refractory Potassium Repletion due to Cisplatin-Induced …

Category:Effect of Silymarin Administration on Cisplatin …

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Cisplatin potassium wasting

Refractory Potassium Repletion due to Cisplatin-Induced …

WebCisplatin for injection is a highly emetogenic antineoplastic agent; premedicate with anti-emetic agents; without antiemetic therapy, marked nausea and vomiting occur in almost … WebClinical implications of potassium depletion Protective effect of potassium Hypokalemia Potassium supplementation strategies: prevention vs repletion Compliance issues and potassium replacement therapy Potassium repletion and the role of magnesium Consensus guidelines for the use of potassium replacement in clinical practice Article …

Cisplatin potassium wasting

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WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin … WebJul 18, 2024 · Cisplatin may cause hypomagnesemia by downregulating the TRPM6/EGF pathway. Of note, Mg co‐administration mitigates both cisplatin‐induced …

Webis an uncommon genetic disorder characterized by renal potassium and sodium wasting, excessive production of renin and aldosterone, and normotension. Gitelman syndrome is caused by loss of function mutations in a thiazide-sensitive ion … WebOne way your body regulates blood potassium levels is by shifting potassium into and out of cells. When there is a breakdown or destruction of cells, the electrolyte potassium moves from inside of the cell to outside of the cell wall. This shift of potassium outside of the cells causes hyperkalemia.

WebCisplatin is a potent antineoplastic agent derived from platinum and commonly used in the treatment of head and ... water restrictions and sodium supplementation may be appropriate when differentiating between diagnoses of renal salt wasting syndrome and syndrome of inappropriate antidiuretic hormone secretion. Fed Pract. 2024 December;38(12 ...

Web42%–100% of patients depending on total cisplatin dose and length of exposure. Hypomagnesemia and renal magnesium wasting may persist for up to 6 years after initial dose (5). Renal salt wasting syndrome has been reported in up to 10% of patients, manifesting as hyponatremia and severe ortho-static hypotension in the setting of high …

WebCisplatin was the first platinum compound to be introduced as a chemotherapeutic agent with antineoplastic activity against a wide variety of solid tumors. Renal … high yield income bondsWebRefractory Potassium Repletion due to Cisplatin-Induced Magnesium Depletion JAMA Internal Medicine JAMA Network • Cisplatin is a common cause of hypomagnesemia … high yield funds in sideways marketsWebCisplatin is known to induce Fanconi syndrome and renal salt wasting (RSW). RSW typically only requires transient normal saline (NS) support. We report a severe RSW case that required 12 liters of 3% saline. A 57-year-old woman with limited stage small cell cancer was admitted for cisplatin (80 mg/m 2) and etoposide (100 mg/m 2) therapy. high yield health savings accountWebFeb 5, 2014 · Cisplatin is one of the most potent and valuable chemotherapy agents available, and is used to treat a broad spectrum of malignancies, with cisplatin … small kitchen table and chairs at argosWebJan 12, 2024 · A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia. J Clin … high yield energy bond etfWebwasting due to cisplatin therapy. Although patients with cancer have hyponatremia due to many etiologies (Table 1), SIADH is the most common etiol-ogy that is directly … high yield index fund listWebNational Center for Biotechnology Information small kitchen stoves ovens