Nettet27. apr. 2024 · Integrins are a large family of adhesion molecules that mediate cell-cell and cell-extracellular matrix interactions. Among the 24 integrin isoforms, many have been found to be associated with tumor angiogenesis, … Nettet14. apr. 2024 · Furthermore, β1 integrins strengthen the adhesion of mitotic cells to adjacent cells, which is supported by vinculin, kindlin, and talin1. ... Cancer Biol. 15, …
Integrins in cancer: biological implications and therapeutic ...
NettetAbstract. Interactions between cancer cells and their surroundings can trigger essential signaling cues that determine cell fate and influence the evolution of the … NettetThe exosomal integrins promote the growth of metastatic cells. Expression of certain integrins is associated with increased metastasis and decreased prognosis in cancers. … caerphilly election 2022
Mechanisms of Matrix-Induced Chemoresistance of Breast Cancer …
NettetIntegrin expression varies depending on tumor type and tissue context. They may overlap in ligand-binding specificity and coordinate adaptive signaling to promote DNA damage repair, cell survival, and tumor progression ( Ahmed et al., 2024; Winograd-Katz et al., 2014; Eke and Cordes, 2015; Janes and Watt, 2004; Hodkinson et al., 2006 ). Nettet12. jul. 2024 · Integrins and integrin-dependent processes have been implicated in almost every step of cancer progression, including cancer initiation and proliferation, local … Nettet6. des. 2024 · Although those protumorigenic effects of integrins in breast cancer have not been considered in terms of CAM-DR, a link between integrins and malignancy of breast cancers could be elucidated. Amongst others, a doxorubicin and epirubicin-resistance in MDA-MB-231 and Hs578T breast cancer cells was found to be related to … caerphilly election results 2022