WebPromethazine. Promethazine, sold under the brand name Phenergan among others, is a first-generation antihistamine, antipsychotic, sedative, and antiemetic used to treat allergies, insomnia, and nausea. It may also help with some symptoms associated with the common cold [4] and may also be used for sedating people who are agitated or anxious, an ...
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WebJan 15, 2024 · Annual review of pharmacology and toxicology, 36(1), 233-252. Twitter Facebook Pinterest LinkedIn Buffer Email Print SMS WhatsApp Messenger Copy Share Categories Notes , Nursing Pharmacology Tags allergic rhinitis , anticholinergic , Antihistamines , diphenhydramine , erythromycin , ketoconazole , promethazine WebPharmacology of antihistamine antiemetics Promethazine is widely prescribed for motion sickness and vestibular disorders; it also can help with raised intracranial pressure. It has little anticholinergic activity. The antiemetic dose is 12.5 to 25 mg PO/IV every 4 to 6 hours (maximum 100 mg/day). flats to rent in theale
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WebSevere Tissue Injury, Gangrene. promethazine injection can cause severe chemical irritation and tissue damage including burning, pain, thrombophlebitis, tissue necrosis and gangrene regardless of administration route; may result from perivascular extravasations, unintentional intra-arterial injection, and intraneuronal or perineuronal ... WebApr 17, 2024 · BOX 1 Pharmacokinetics of promethazine. Oral promethazine is almost completely absorbed from the gut and metabolised by hydroxylation (involving the hepatic enzyme CYP 2D6) and sulphoxidation in the liver, leading to a bioavailability of 25% and a peak concentration at 2–4 h. The peak is at 2 h after intramuscular (IM) administration. WebFeb 15, 2024 · Ondansetron is one of the medications most commonly used for the empiric treatment of nausea and vomiting. Ondansetron has excellent utility as an antiemetic drug, and it is effective against nausea … flats to rent in thornhill dewsbury