WebFeb 1, 2024 · Phosphoramide mustard-hemoglobin (PAM-Hb) The exposure of cyclophosphamide is determined via PAM-Hb, assessed from blood samples drawn after each course of each patient. An optimized and... WebMar 1, 1976 · Summary. The relative alkylating activities of two of the cytotoxic metabolites of cyclophosphamide, phosphoramide mustard and nornitrogen mustard, have been …
Design and synthesis of peptide conjugates of
WebNov 9, 2012 · Cyclophosphamide is inactive until it undergoes hepatic transformation to form 4-hydroxycyclophosphamide, which then breaks down to form the ultimate alkylating agent, phosphoramide mustard. Sensitive and specific methods are now available for the measurement of cyclophosphamide, its metabolites and its stereoisomers in plasma and … WebMar 2, 2024 · Ifosfamide belongs to the class of the oxazaphosphorine alkylating agents. It is an inactive compound in its parent form (prodrug). It is metabolized in the liver by CYP450 enzymes to active metabolites. These active metabolites (phosphoramide mustard derivatives and acrolein) bind to DNA and inhibit DNA synthesis. [13] highneal limited
Protonation of phosphoramide mustard and other phosphoramides
WebJun 1, 1995 · The Partitioning of Phosphoramide Mustard and Its Aziridinium Ions among Alkylation and P−N Bond Hydrolysis Reactions. Journal of Medicinal Chemistry 1998 , 41 (4) , 515-529. WebMar 1, 1976 · Summary. The relative alkylating activities of two of the cytotoxic metabolites of cyclophosphamide, phosphoramide mustard and nornitrogen mustard, have been studied at pH 4.6 and 7.4. The products formed on alkylation of ethanethiol by these metabolites have been identified, confirming that phosphoramide mustard undergoes alkylation … WebApr 18, 2006 · In contrast to 4-hydroxycyclophosphamide, phosphoramide mustard cannot enter target cells, and therefore only the intracellularly formed phosphoramide mustard fraction is considered to be cytotoxic. highnature co. ltd