Photocleavable spacer

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August undefined, 2024

WebAug 1, 1995 · This reagent contains a biotin moiety linked through a spacer arm to a photocleavable moiety, which reacts selectively with primary amino groups on any … http://genelink.com/newsite/products/mod_detail.asp?modid=134

Photocleavable linkers: design and applications in …

WebPhotocleavable DBCO-NHS ester reagent contains an amine reactive group linked to DBCO moiety through a spacer arm containing a photocleavable moiety. Molecules jointed by the copper-free click reaction can be efficiently photoreleased, typically >90% in 5-25 minutes using an inexpensive, near-UV, low intensity lamp (e.g. 365 nm lamp at 1-5 mW ... WebBio-Synthesis offers photocleavable PC Biotin Oligo Modification at various scales. This light activatable PC biotin modified oligonucleotide contained a photocleavable spacer between the biotin group and the DNA bases. The biotin group is separated from the 5' end nucleotide base by the photo-cleavable group and a long chain spacer arm. easter 1767

(PDF) Control of Ligand-Binding Specificity Using Photocleavable ...

WebSpacer Modifiers. The hydrophilic spacers; Spacer 9 ( LK2128) and Spacer 18 (HEG) ( LK2129) are also particularly useful to build in flexibility within an oligo sequence. 6. As with 3’-‘spacers’ these are known to be nuclease … WebPhotocleavable DBCO-NHS ester reagent contains an amine reactive group linked to DBCO moiety through a spacer arm containing a photocleavable moiety. 订购说明： 1、绝大部分产品备有现货，一般情况下都能订货当日发货。 2、部分非常用产品，需提前1－2日预订，海外期货则需要提前3-6周预订。 WebPhotocleavable spacer modified oligonucleotides could be used to tether an antisense oligo to a dextran, which is too large to pass through the nuclear pores. Photocleavage would … easter 1756

Abasic Site (dSpacer abasic furan-THF) - Gene Link

Photocleavable biotin derivatives: a versatile approach for the ... - PNAS

WebPC Biotin Alkyne an azide-reactive photocleavable biotin probe that allows for reagent-free release of the captured biomolecules from streptavidin. This reagent contains a biotin moiety linked to an azide group through a spacer arm containing a photocleavable moiety. Captured biomolecules can be efficiently photoreleased, typically >90% in 5-25 ... http://www.rx-8.com/chanpinzhongxin/210204.html cub scout hiking lost clipartWebThe PC spacer (LK2131) and PC linker (LK2066) amidites can be incorporated within an oligonucleotide sequence. This is particularly useful in adding a modifier as a phosphoramidite where there is a need to remove this from the oligonucleotide at a later stage. ... Photocleavable Peptide-Oligonucleotide Conjugates for Protein Kinase Assays … easter 1707

"WebJan 1, 2024 · Applying a photocleavable linker in drug conjugation serves as an effective strategy for actively controlling such payload release using a light stimulus. This chapter … " - Photocleavable spacer

Photocleavable spacer

Photocleavage of a 2-nitrobenzyl linker bridging a fluorophore ... - PNAS

WebApr 22, 2024 · imparted by the insertion of the photocleavable spacer could allow more orientational freedom for biotin, resulting in a higher number of detected avidin − biotin interactions. WebPhotocleavable biotin is a type of small molecule probe that is commonly used in biological research and diagnostics. It belongs to the family of cleavable biotin probes, which are …

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http://genelink.com/newsite/products/mod_detail.asp?modid=18 WebThe light-triggered release of paclitaxel or fluorophore Cy5 was achieved by incorporation of photocleavable spacers into the RNA nanoparticles. Upon irradiation with ultraviolet light, cargos were rapidly released (within 5 min). In vitro treatment of breast cancer cells with the RNA nanoparticles harboring photocleavable paclitaxel showed ...

WebFeb 5, 2010 · DNAzymes incorporating photocleavable spacers were switched “on” or “off” with light. A DNAzyme (left) with two photocleavable spacers, in a binding arm and the catalytic core, lost the ability to hydrolyze RNA upon UV photolysis. Conversely, a circular DNAzyme (right) attached to a self-complementary strand via two photocleavable ... WebThe spacer phosphoramidites C3, 9, C12 and 18 are used to insert a spacer arm in an oligonucleotide. The compounds may be added in multiple additions when a longer …

WebAug 2, 2024 · Figure 3: A photocleavable biotin spacer useful for phosphoramidite oligonucleotide synthesis. This spacer allows the capture of modified oligonucleotides using the streptavidin system and the rapid, quantitative removal of the biotin spacer using near UV light at 300 to 350 nm. The released oligonucleotides are now suitable for other ... WebAug 1, 1995 · While the strong biotin-avidin interaction has been widely used for the detection of biomolecules, its irreversibility complicates their isolation. We report the synthesis of a photocleavable biotin derivative (PCB) which eliminates many limitations of existing methods. This reagent contains a biotin moiety linked through a spacer arm to a ...

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WebPhotocleavable PC linker contained a non-nucleosidic group that can be used to link two nucleotide sequences through a short, UV photo-cleavable C3 spacer arm. Upon … cub scout hiking patchesWebIMAGING SPACERS. Imaging spacers are ultra-thin adhesive spacers which peel-and-stick to coverglass or microscope slides to confine specimens without compression. Layer … easter 18WebPC Spacer is a photocleavable C3 spacer modifier. Our ability. We provide a flexible ordering model to quickly meet your order requirements, whether it is a large number of standard products or customized products. With a GLP laboratory and unique technology development, we can help you meet the ever-changing market needs. ... cub scout hiking trails in washington countyWebSep 17, 2024 · In vitro treatment of breast cancer cells with the RNA nanoparticles harboring photocleavable paclitaxel showed higher cytotoxicity as compared to RNA nanoparticles without the photocleavable spacer. The methodology provides proof of concept for the application of the light-triggered controlled release of drugs from RNA nanocages. … easter 1795WebAug 1, 1995 · This reagent contains a biotin moiety linked through a spacer arm to a photocleavable moiety, which reacts selectively with primary amino groups on any substrate. In experiments using [leucine]-enkephalin as a model substrate, we show that PCB retains its high affinity toward avidin/streptavidin and allows rapid (< 5 min) and … easter 1815WebStorage Conditions: -20°C To -70°C. Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free … easter 1568WebPhotocleavable Azido-NHS ester reagent contains an amine reactive group linked to azido moiety through a spacer arm containing a photocleavable moiety. Molecules jointed through photocleavable linker can be efficiently photoreleased, typically >90% in 5-25 minutes using an inexpensive, near-UV, low intensity lamp (e.g. 365 nm lamp at 1-5 mW/cm 2). easter 1810