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WebThis causes the adrenocortical cells to release the glucocorticoids from the zona fasciculata, which have powerful anti-inflammatory and metabolic effects. These glucocorticoids have a negative feedback effect on the hypothalamic-pituitary-adrenal axis, meaning excess corticosteroids suppress the release of both CRH and ACTH into the … WebCommon side effects of prednisolone, especially with high doses for long periods, include: fluid retention, which can lead to heart problems. trouble sleeping. bloating of the face and swelling of the abdomen. weight gain. irregular periods. muscle cramps. thin skin with easy bruising and acne. space maths activities
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