Webb5 nov. 2008 · T-2 toxin is a cytotoxic secondary fungal metabolite that belongs to the trichothecene mycotoxin family. This mycotoxin is a well known inhibitor of protein synthesis through its high binding affinity to peptidyl transferase, which is an integral part of the ribosomal 60s subunit, and it also inhibits the synthesis of DNA and RNA, probably … WebbBesides apoptosis and the cell cycle, p53 also controls other processes, such as senescence, 17 autophagy, 18, 19 angiogenesis, 20 and DNA repair. 21 Given its key role in protecting cells, p53 activation is tightly regulated. Indeed, the half-life of p53 is short under normal conditions, and is regulated by numerous E3 and E4 ligases.
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Webb30 mars 2024 · We have investigated the consequences of activating the Kit signalling pathway by its ligand Steel factor on these opposing functions of the p53 protein in … WebbThe ADP-ribosylation factor-like (ARL) family, as a subfamily of small G proteins, has been implicated in a wide variety of essential cellular functions including vesicular trafficking, cytoskeletal organization, ciliogenesis, cell proliferation, motility and differentiation. 5–7 In the recent years, accumulating evidences demonstrate the crucial effects of ARL family … lc\\u0027s asian kitchen madison heights
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Webb8 apr. 2024 · This was accompanied by elevated expression of p53, decreased Cox-2 activity as a result of the downregulation of the activator protein 1 (AP-1) signaling … Webb11 apr. 2024 · Yeasts have been a part of human life since ancient times in the fermentation of many natural products used for food. In addition, in the 20th century, they became powerful tools to elucidate the functions of eukaryotic cells as soon as the techniques of molecular biology developed. Our molecular understandings of … WebbThe protein ( C) and mRNA ( D) levels of YB-1, MDM2, and p53 were analyzed by Western blot and qRT-PCR after overexpression or knockdown of YB-1 in U87 and DK-MG cells. * P <0.05, ** P <0.01, *** P <0.001 vs the control group. Abbreviations: CCK-8, cell counting kit-8; qRT-PCR, quantitative real-time PCR; TMZ, temozolomide. lc\u0027s family style restaurant